Journal
VIROLOGY
Volume 504, Issue -, Pages 152-167Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.01.022
Keywords
Negevirus; Nelorpivirus genus; Sandewavirus genus; Insect-specific viruses; Virus diversity
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Funding
- NIH [U54 A1057156, R24 AI120942, HHSN272202000040I/HHSN200004/D04]
- Programa de Doctorados Nacionales Colciencias [567]
- Colciencias [C.T-695-2014, 111549326198]
- CNPq (Brazilian National Council for Research and Development) [302032/2011-8]
- Yale Institute for Biospheric Studies Center for EcoEpidemiology
- U.S. National Park Service [EVER-2013-SCI-0032]
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The recently described taxon Negevirus is comprised of a diverse group of insect-specific viruses isolated from mosquitoes and phlebotomine sandflies. In this study, a comprehensive genetic characterization, molecular, epidemiological and evolutionary analyses were conducted on nearly full-length sequences of 91 new negevirus isolates obtained in Brazil, Colombia, Peru, Panama, USA and Nepal. We demonstrated that these arthropod restricted viruses are clustered in two major phylogenetic groups with origins related to three plant virus genera (Cilevirus, Higrevirus and Blunevirus). Molecular analyses demonstrated that specific host correlations are not present with most negeviruses; instead, high genetic variability, wide host-range, and cross-species transmission were noted. The data presented here also revealed the existence of five novel insect-specific viruses falling into two arthropod-restrictive virus taxa, previously proposed as distinct genera, designated Nelorpivirus and Sandewavirus. Our results provide a better understanding of the molecular epidemiology, evolution, taxonomy and stability of this group of insect-restricted viruses.
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