Journal
VIROLOGY
Volume 501, Issue -, Pages 166-175Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2016.11.014
Keywords
Sinu virus; Orthomyxoviridae; Thogotovirus genus; Insect-specific viruses
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Funding
- Colombian Department of Science (Colciencias Convocatoria) [567]
- Colciencias [111549326198]
- NIH [R24 AI120942]
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The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
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