Journal
VIROLOGY
Volume 507, Issue -, Pages 89-95Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.04.013
Keywords
Zika virus; STAT2; Hamsters; Fetus; Testes
Categories
Funding
- Public Health Service (PHS) from the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) [1R21NS090133-01A1, 5R21NS088400-02]
- PHS from the Virology Branch, National Institute of Allergy and Infectious Diseases (NIAID), NIH [5R33AI101483, HHSN272201000039I/HHSN27200004]
- Utah Agriculture Research Station research from the Next Generation BioGreen 21 Program [UTA01176, PJ01107703]
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Zika virus (ZIKV) infection was investigated in adult and fetal STAT2 knock-out (KO) hamsters. Subcutaneous injection of ZIKV of adults resulted in morbidity, mortality, and infection of the uterus, placenta, brain, spinal cord, and testicles, thus providing an opportunity to evaluate congenital ZIKV infection in a second rodent species besides mice. ZIKV-infected cells with morphologies of Sertoli cells and spermatogonia were observed in the testes, which may have implications for sexual transmission and male sterility. Neonates exposed as fetuses to ZIKV at 8 days post-coitus were not smaller than controls. Nevertheless, infectious virus and ZIKV RNA was detected in some, but not all, placentas and fetal brains of KO hamsters. STAT2 KO hamsters may be useful for addressing sexual transmission, pathogenesis, routes of fetal infection, and neurological disease outcomes, and may also be used in antiviral or vaccine studies to identify intervention strategies.
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