Journal
VIROLOGY
Volume 511, Issue -, Pages 49-55Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.08.003
Keywords
Neural progenitor cells; Mouse hepatitis virus; Viral receptor; Cytopathology
Categories
Funding
- National Institutes of Health (NIH) [R01N5092042, R01N5074978]
- California Institute for Regenerative Medicine (CIRM) [TR3-05603]
- NIH [NS82174, 5T3232A1007319]
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The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-gamma treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed.
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