Journal
VIROLOGY
Volume 512, Issue -, Pages 8-20Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.08.035
Keywords
Highly pathogenic avian influenza A viruses; H5N6; Glade 2.3.4.4; Poultry; Wild bird
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Funding
- Japan Agency for Medical Research and Development (AMED)
- Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan
- research project for improving food safety and animal health of the Ministry of Agriculture, Forestry, and Fisheries of Japan
- Russian Science Foundation [17-44-07001] Funding Source: Russian Science Foundation
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To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively. Six gene segments originated from a putative ancestral Glade 2.3.4.4 H5N6 virus that was a possible genetic reassortant among Chinese Glade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 3 distinct AIV-derived PA clusters were evident. These results suggest that migratory birds were important in the spread and genetic diversification of Glade 2.3.4.4 H5 HPAIVs.
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