Journal
AMERICAN JOURNAL OF DERMATOPATHOLOGY
Volume 39, Issue 10, Pages 738-741Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0000000000000781
Keywords
galectin-3; basal cell carcinoma; squamous cell carcinoma; epidermal hyperplasia
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Funding
- National Natural Science Foundation of China [81472887, 81402608]
- Natural Science Foundation of Guangdong Province [S2013010014957, S2011010003664]
- Science and technology project in Guangzhou [2014J4100040]
- Health care collaborative innovation major projects in Guangzhou [201400000002]
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Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6.0. We found that galectin-3 distributed evenly in normal skin around the body decreased significantly in all selected diseases compared with healthy controls, but it was comparable among each disease. These findings imply that galectin-3 do not differentiate between benign and malignant proliferation of keratinocytes.
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