Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 44, Pages 38870-38876Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b15237
Keywords
micromachine; topographical manipulation; acoustic microstreaming; microrotor; dynamic assembly; biological isolation
Funding
- Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense [HDTRA1-14-1-0064]
- National Natural Science Foundation of China [51505222]
- China Scholarship Council (CSC)
- UC MEXUS-CONACYT
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Precise and reproducible manipulation of synthetic and biological microscale objects in complex environments is essential for many practical biochip and microfluidic applications. Here, we present an attractive acoustic topographical manipulation (ATM) method to achieve efficient and reproducible manipulation of diverse microscale objects. This new guidance method relies on the acoustically induced localized microstreaming forces generated around microstructures, which are capable of trapping nearby microobjects and manipulating them along a determined trajectory based on local topographic features. This unique phenomenon is investigated by numerical simulations examining the local microstreaming in the presence of microscale boundaries under the standing acoustic wave. This method can be used to manipulate a single microobject around a complex structure as well as collectively manipulate multiple objects moving synchronously along complicated shapes. Furthermore, the ATM can serve for automated maze solving by autonomously manipulating microparticles with diverse geometries and densities, including live cells, through complex maze-like topographical features without external feedback, particle modification, or adjustment of operational parameters.
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