Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 46, Pages 14723-14726Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708037
Keywords
carbonyl radicals; C-H activation; hydrogen-atom transfer; hypervalent compounds; photocatalysis
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Funding
- NRW Graduate School of Chemistry
- Deutsche Forschungsgemeinschaft
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The development of new hydrogen-atom transfer (HAT) strategies within the framework of photoredox catalysis is highly appealing for its power to activate a desired C-H bond in the substrate leading to its selective functionalization. Reported here is the first photoredox-mediated hydrogen-atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio- and chemoselectivity by direct functionalization of C-sp2(O)-H bonds. The broad synthetic application of this method has been demonstrated by the selective functionalization of C(O)-H bonds within complex molecular scaffolds.
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