4.8 Article

Asymmetric Intermolecular Heck Reaction of Propargylic Acetates and Cycloalkenes to Access Fused Cyclobutenes

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 46, Pages 14567-14571

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708435

Keywords

cyclobutene; Heck reaction; palladium; propargylic electrophiles; strained rings

Funding

  1. Singapore Ministry of Education Academic Research Fund [MOE2014-T1-001-021, MOE2015-T1-001-166]

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An asymmetric Heck annulation of propargylic acetates with several types of cyclic olefins affords highly strained cyclobutenes in high enantioselectivity.

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