Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 25, Issue 22, Pages 6149-6166Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.01.002
Keywords
Antibiotics; Anticancer; Biofilm; Biosynthesis; Natural product; Phenazine
Funding
- ERA-Chemistry network - Deutsche Forschungsgemeinschaft (DFG) [BL587-3]
- Austrian Science Fund (FWF) [I-668]
- NAWI Graz
- BioTechMed Graz
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Phenazines are natural products which are produced by bacteria or by archaeal Methanosarcina species. The tricyclic ring system enables redox processes, which producing organisms use for oxidation of NADH or for the generation of reactive oxygen species (ROS), giving them advantages over other microorganisms. In this review we summarize the progress in the field since 2005 regarding the isolation of new phenazine natural products, new insights in their biological function, and particularly the now almost completely understood biosynthesis. The review is complemented by a description of new synthetic methods and total syntheses of phenazines. (C) 2017 The Authors. Published by Elsevier Ltd.
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