Journal
EUROPEAN HEART JOURNAL
Volume 36, Issue 30, Pages 1974-+Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehv087
Keywords
Baroreceptor reflex; Chemoreceptor reflex; Exercise; Heart failure; Human; Parasympathetic nervous system; Sleep apnoea; Sympathetic nervous system
Categories
Funding
- Tier 1 Canada Research Chair in Integrative Cardiovascular Biology
- Heart and Stroke Foundation of Ontario
- Canadian Institutes of Health Research
- Polish National Science Centre
- Wroclaw Medical University
- Cibiem
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Cardiovascular autonomic imbalance, a cardinal phenotype of human heart failure, has adverse implications for symptoms during wakefulness and sleep; for cardiac, renal, and immune function; for exercise capacity; and for lifespan and mode of death. The objectives of this Clinical Review are to summarize current knowledge concerning mechanisms for disturbed parasympathetic and sympathetic circulatory control in heart failure with reduced ejection fraction and its clinical and prognostic implications; to demonstrate the patient-specific nature of abnormalities underlying this common phenotype; and to illustrate how such variation provides opportunities to improve or restore normal sympathetic/parasympathetic balance through personalized drug or device therapy.
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