Journal
VETERINARY PARASITOLOGY
Volume 243, Issue -, Pages 79-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2017.06.003
Keywords
Chicken; Eimeria; EF-1 alpha; Coccidiosis; Immune protection
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Funding
- ARS CRIS [8042-32000-107-00D]
- Scientific and Technological Programs of Guangdong Province from People's Republic of China [2012A020100001]
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Avian coccidiosis is caused by multiple species of the apicomplexan protozoan, Eimeria, and is one of the most economically devastating enteric diseases for the poultry industry worldwide. Host immunity to Eimeria infection, however, is relatively species-specific. The ability to immunize chickens against different species of Eimeria using a single vaccine will have a major beneficial impact on commercial poultry production. In this paper, we describe the molecular cloning, purification, and vaccination efficacy of a novel Eimeria vaccine candidate, elongation factor-1 alpha (EF-1 alpha). One day-old broiler chickens were given two subcutaneous immunizations one week apart with E. toll-expressed E. tenella recombinant (r)EF-1 alpha protein and evaluated for protection against challenge infection with E. tenella or E. maxima. rEF-1 alpha-vaccinated chickens exhibited increased body weight gains, decreased fecal oocyst output, and greater serum anti-EF-1 alpha antibody levels following challenge infection with either E. tenella or E. maxima compared with unimmunized controls. Vaccination with EF-1 alpha may represent a new approach to inducing cross-protective immunity against avian coccidiosis in the field.
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