Journal
ACTA TROPICA
Volume 176, Issue -, Pages 224-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2017.08.015
Keywords
Taenia hydatigena; Echinococcus granulosus; Metacestode; Cyst fluid
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Funding
- National Key Basic Research Program (973 program) of China [2015CB150300]
- National Natural Science Foundation of China [31201900, 31472185]
- Central State Public-interest Scientific Institution Basal Research Fund [1610312016017]
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Taenia hydatigena is a parasitic flatworm that is widely distributed around the world. Using MS/MS, the proteome of T. hydatigena cyst fluid (CF) was profiled and a total of 520 proteins were identified, 430 of which were of sheep origin. T. hydatigena shared 37 parasite-origin and 109 host-origin CF proteins with Echinococcus granulosus. Compared with E. granulosus, T. hydatigena had much more CF proteins associated with amino acid synthesis and complement cascades. In addition, glutamate metabolism and anti-oxidative reactions were identified as relatively more important events. These results suggest that T. hydatigena metacestodes have internal microenvironment with special immune and oxidative conditions.
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