Journal
CATALYSIS COMMUNICATIONS
Volume 102, Issue -, Pages 35-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.catcom.2017.08.023
Keywords
4-Oxodecanoic acid; 5-Oxodecanoic acid; (R)-gamma-Decalactone; (R)-delta-Decalactone; Carbonyl reductase; Asymmetric reduction
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Funding
- National Key Research and Development of China [2016YFA0204300]
- National Natural Science Foundation of China [21505044, 21536004, 21776085]
- Shanghai Pujiang Program [15PJ1401200]
- Fundamental Research Funds for the Central Universities [222201714026]
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A novel carbonyl reductase from Serratia marcescens, SmCR, was successfully cloned and overexpressed in Escherichia coil. SmCR could catalyze the asymmetric reduction of long-chain keto acids/esters containing remote carbonyl groups, such as 4-oxo- and 5-oxodecanoic acids, yielding chiral gamma- and delta-decalactones with high en-antiopurity (up to 99% ee). This is the first report of enzymatic synthesis of (R)-gamma- and (R)-delta-decalactones starting from gamma-, delta-keto acids using free enzymes.
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