Journal
VETERINARY PARASITOLOGY
Volume 244, Issue -, Pages 172-175Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2017.07.005
Keywords
Natural products; Rotenoid; Rotenone; Deguelin; Haemonchus contortus
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Funding
- Australian Research Council (ARC)
- Yourgene Bioscience (Taiwan)
- University of Melbourne (RBG)
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The control of parasitic roundworms (nematodes) is heavily reliant on the use of a limited number of anthelmintic drugs. However, drug resistance is now very widespread and no vaccines are available, such that the discovery of new chemical entities is crucial. Within this context, we screened a library of pure natural products (n = 400) against exsheathed third-stage (xL3) larvae of the parasitic nematode Haemonchus contortus using a whole-organism screening method. We identified two plant-derived rotenoids, deguelin and rotenone, with inhibitory activity on xL3 motility. Rotenone was not investigated further, because of its toxicity to some vertebrates. The dose response and cytotoxicity studies showed potent and selective inhibitory activity of deguelin on motility of xL3 larvae of H. contortus. Detailed future work needs to be conducted to explore the mode of action of this compound on H. contortus and related nematodes, and to assess its potential as an anthelmintic candidate.
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