Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 89, Pages 12124-12127Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc06547g
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Funding
- NSFC [21372002, 21232007]
- PAPD
- Natural Science Foundation of Jiangsu Province [BK20160003]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX17_1577]
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The first catalytic asymmetric arylative dearomatization of tryptophols has been established. By using quinone imine ketals as aryl group surrogates and modulating the reaction conditions, the cascade reaction of tryptophols with quinone imine ketals in the presence of chiral phosphoric acid afforded two series of arylative dearomatization products with generally high yields (up to 99%), and excellent diastereo- and enantioselectivities (all > 95 : 5 dr, 90% to 99% ee) in a chemoselective manner.
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