Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 47, Issue 11, Pages 3489-3496Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-017-3246-6
Keywords
Autism; ASD; Antidepressants; SSRI; Genetics
Categories
Funding
- Simons Foundation [89368]
- National Institute of Mental Health [01MH100047]
- Medical Student Research Training Program (MSRTP), University of Washington School of Medicine, Seattle, WA
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To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a two-hit model in which one variable lays the foundation for an initial risk which is compounded by a second variable.
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