Journal
VETERINARY MICROBIOLOGY
Volume 206, Issue -, Pages 29-34Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2016.09.014
Keywords
Heterologous protection; Immune evasion; Genetic diversity; DNA shuffling; Consensus immunogens; Chimeric virus
Categories
Funding
- US National Pork Board [15-159]
- Agriculture and Food Research Initiative Competitive from the USDA National Institute of Food and Agriculture [2016-67015-24922, 2013-01035]
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Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens currently affecting swine production worldwide. Although PRRS vaccines have been commercially available for over 20 years, the available vaccines are considered inadequately effective for control and eradication of the virus. Major obstacles for the development of a highly effective PRRS vaccine include the highly variable nature of the viral genome, the viral ability to subvert the host immune system, and the incomplete understanding of the immune protection against PRRSV infection. This article summarizes the impediments for the development of a highly protective PRRS vaccine and reviews the vaccinology approaches that have been attempted to overcome one of the most formidable challenges, which is the substantial genetic variation among PRRSV isolates, to broaden the antigenic coverage of PRRS vaccines. (C) 2016 Elsevier B.V. All rights reserved.
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