Journal
VETERINARY JOURNAL
Volume 228, Issue -, Pages 18-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2017.10.002
Keywords
Drug resistance; Inflammation; Immune response; Lymphoma; Microenvironment
Categories
Funding
- Japan Society for the Promotion of Science, KAKENHI [17H03921, 17H05043, 24658265, 15K14864, 11J03651]
- Grants-in-Aid for Scientific Research [24658265, 15K14864, 17H05043, 17H03921, 11J03651] Funding Source: KAKEN
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The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma. (C) 2017 Elsevier Ltd. All rights reserved.
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