Journal
VETERINARY JOURNAL
Volume 222, Issue -, Pages 9-16Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2017.02.007
Keywords
Bovine tuberculosis; Co-infection; Fasciolosis; Johne's disease; Immunomodulation
Categories
Funding
- EU [635408]
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Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale. This review explores the immunological consequences of co-infection between F hepatica and other bacterial infections. Arguments are presented suggesting that immunity of cattle to Mycobacterium avium subsp. paratuberculosis is also likely to be affected. (C) 2017 Elsevier Ltd. All rights reserved.
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