Journal
VETERINARY JOURNAL
Volume 230, Issue -, Pages 62-64Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2017.10.009
Keywords
Zika virus; Semliki Forest virus; Lipid biosynthesis; Antiviral agent
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Funding
- UK Medical Research Council [MC_UU_12014, MR/N017552/1]
- MRC [MC_UU_12014/8, MR/N017552/1] Funding Source: UKRI
- Medical Research Council [1650827, MR/N017552/1, MC_UU_12014/8] Funding Source: researchfish
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The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae). (C) 2017 The Authors. Published by Elsevier Ltd.
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