Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 190, Issue -, Pages 53-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2017.07.001
Keywords
Canine; Urothelial carcinoma; Urinary bladder; Tumor-infiltrating lymphocytes; Anti-tumor immunity
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Funding
- JSPS (KAKENHI) [16H06208]
- Grants-in-Aid for Scientific Research [15KK0275, 16K15045, 16H06208] Funding Source: KAKEN
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Although tumor-infiltrating lymphocytes (TILs) play a key role in anti-tumor immunity, their involvement in canine transitional cell carcinoma (TCC) is not well-documented. The objective of this study was to investigate the association between TIL number and prognosis in dogs with urinary bladder TCC. Immunohistochemical analysis of CD3 and granzyme B was performed using canine TCC (n = 32) and normal bladder (n = 10) tissues. The numbers of CD3(+) and granzyme B+ cells located in peritumoral stroma of canine TCC were significantly higher than those in normal controls. In TCC cases, the number of CD3(+) TILs was not significantly related to prognosis, whereas the abundant granzyme Ms were associated with favorable outcome. Since granzyme B+ TILs were not associated with the tumor stage, the presence of granzyme TILs may be an independent prognostic factor. These results suggest that granzyme TILs play a role in anti-tumor immunity and inhibit tumor progression in canine TCC.
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