4.7 Article

Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan

Journal

EMERGING INFECTIOUS DISEASES
Volume 23, Issue 11, Pages 1872-1875

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2311.170833

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Funding

  1. National Health and Medical Research Council [0606788, 1092262]
  2. Wellcome Trust [206194]
  3. Higher Education Commission of Pakistan
  4. Children's Hospital & The Institute of Child Health, Lahore, Pakistan
  5. Higher Education Commission Pakistan under the International Research Support Initiative Program

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Klebsiella pneumoniae shows increasing emergence of multidrug-resistant lineages, including strains resistant to all available antimicrobial drugs. We conducted whole-genome sequencing of 178 highly drug-resistant isolates from a tertiary hospital in Lahore, Pakistan. Phylogenetic analyses to place these isolates into global context demonstrate the expansion of multiple independent lineages, including K. quasipneumoniae.

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