Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 11, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01423-17
Keywords
polymyxin; rapid polymyxin NP test; susceptibility testing; resistance mechanisms; CrrAB; Klebsiella pneumoniae
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Funding
- University of Bordeaux
- University of Fribourg
- ANIWHA ERA-NET project, Switzerland
- Office Federal de la Sante Publique, Bern, Switzerland [16009294]
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Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype.
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