Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 17, Issue 11, Pages 2911-2921Publisher
WILEY
DOI: 10.1111/ajt.14310
Keywords
-
Categories
Funding
- Arbor Research Collaborative for Health in Ann Arbor, MI [HHSH234200537009C]
- SEER Program of the National Cancer Institute: California [HHSN261201000036C, HHSN261201000035C, HHSN261201000034C]
- SEER Program of the National Cancer Institute: Connecticut [HHSN261201000024C]
- SEER Program of the National Cancer Institute: Hawaii [HHSN261201000037C, N01-PC-35137, N01-PC-35139]
- SEER Program of the National Cancer Institute: Iowa [HSN261201000032C, N01-PC-35143]
- SEER Program of the National Cancer Institute: New Jersey [HHSN261201300021, N01-PC-2013-0021]
- SEER Program of the National Cancer Institute: Seattle-Puget Sound [N01-PC-35142]
- SEER Program of the National Cancer Institute: Utah [HHSN2612013000171]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: California [1058 DP000807-01]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Colorado [058 DP000848-04]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Georgia [5058DP003875-01]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Illinois [5U58DP003883-03]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Maryland [U58DP12-1205 3919-03]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Michigan [5U58DP003921-03]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: New Jersey [5058/DP003931-02]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: New York [058DP003879]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: North Carolina [058DP000832]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Texas [5058DP00082/1-04]
- state of California
- state of Colorado
- state of Connecticut
- state of Illinois
- state of Iowa
- state of Massachusetts (Massachusetts Cancer Prevention and Control Cooperative Agreement) [5458DP003920]
- state of New Jersey
- state of New York (Cancer Surveillance Initiative)
- state of Texas
- state of Utah
- state of Washington
- University of Utah
- Fred Hutchinson Cancer Research Center in Seattle, WA
- Intramural Research Program of the National Cancer Institute
Ask authors/readers for more resources
Solid organ transplant recipients have an elevated incidence of thyroid cancer. We evaluated a wide range of potential risk factors in a cohort of 229 300 U.S. solid organ transplant recipients linked with 15 stage/regional cancer registries (1987-2012). Incidence rate ratios (IRRs) were adjusted for age, sex, race/ethnicity, transplanted organ, year of transplantation, and time since transplantation. Hazard ratios (HRs) for death and/or graft failure were adjusted for age, sex, race/ethnicity, transplanted organ, and year of transplantation. After transplantation, 356 thyroid cancers were diagnosed. Thyroid cancer incidence was 2.50-fold higher in transplant recipients than the general population (95% confidence interval [CI] 2.25-2.77). Among recipients of different organs, kidney recipients had the highest incidence of thyroid cancer (IRR = 1.26, 95% CI 1.03-1.53). Elevated thyroid cancer incidence was associated with cholestatic liver disease/cirrhosis as an indication for liver transplantation (IRR = 1.69, 95% CI 1.09-2.63), hypertensive nephrosclerosis as an indication for kidney transplantation (IRR = 1.41, 95% CI 1.03-1.94), and longer prior dialysis among kidney recipients (5+ vs. <1 year, IRR = 1.92, 95% CI 1.32-2.80; p-trend <0.01). Posttransplantation diagnosis of thyroid cancer was associated with modestly increased risk of death (HR = 1.33, 95% CI 1.02-1.73). Overall, our results suggest that end-stage organ disease and longer duration of dialysis may contribute to higher thyroid cancer incidence in transplant recipients.
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