Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 74, Issue 21, Pages 3999-4014Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2614-x
Keywords
Melatonin; Mitochondria; Neurodegeneration; Alzheimer's disease; Parkinson's disease; Huntington's disease
Categories
Funding
- TRF research Grant [DPG5780001]
- Mahidol University research grant
Ask authors/readers for more resources
Mitochondria are crucial organelles as their role in cellular energy production of eukaryotes. Because the brain cells demand high energy for maintaining their normal activities, disturbances in mitochondrial physiology may lead to neuropathological events underlying neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Melatonin is an endogenous compound with a variety of physiological roles. In addition, it possesses potent antioxidant properties which effectively play protective roles in several pathological conditions. Several lines of evidence also reveal roles of melatonin in mitochondrial protection, which could prevent development and progression of neurodegeneration. Since the mitochondrial dysfunction is a primary event in neurodegeneration, the neuroprotection afforded by melatonin is thereby more effective in early stages of the diseases. This article reviews mechanisms which melatonin exerts its protective roles on mitochondria as a potential therapeutic strategy against neurodegenerative disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available