Journal
CHEMCATCHEM
Volume 9, Issue 20, Pages 3989-3996Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201700695
Keywords
arenes; asymmetric synthesis; hydrogenation; lactones; ruthenium
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Funding
- National Natural Science Foundation of China
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Highly enantioselective tandem hydrogenation/lactonization of various 2-acylarylcarboxylates including 2-aroylarylcarboxylates were realized by using [RuCl(benzene)(S)-SunPhos]Cl as the catalyst under mild reaction conditions. Excellent enantioselectivities (up to 99.6% ee) and activities (S/C=1000) were obtained. This convenient and practical method enables a direct access to a series of highly optically pure 3-substituted phthalides that are very important molecules as valuable pharmacological compounds and diversified synthons for medicinal chemistry. Moreover, a gram-scale reaction was performed to further demonstrate the practicality of this approach.
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