Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 82, Pages 11266-11277Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc06574d
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Funding
- NSF [CHE1738305]
- Hundred Talent Program of Shanxi Province, China
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The formation of S-nitrosothiols (SNO) in protein cysteine residues is an important post-translational modification elicited by nitric oxide (NO). This process is involved in virtually every class of cell signaling and has attracted considerable attention in redox biology. On the other hand, their unique structural characters make SNO potentially useful synthons. In this review, we summarized the fundamental chemical/physical properties of SNO. We also highlighted the reported chemical reactions of SNO, including the reactions with phosphine reagents, sulfinic acids, various nucleophiles, SNO-mediated radical additions, and the reactions of acyl SNO species.
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