Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 492, Issue 3, Pages 461-467Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.08.074
Keywords
miR-1236-3p; KLF8; Epithelial mesenchymal transition(EMT); Migration; Invasion
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Funding
- Six talent peaks project in Jiangsu Province, China [WSN-059]
- Key talents of Medical Science in Jiangsu Province, China [QNRC2016682]
- Scientific research topic of Jiangsu provincial health and Family Planning Commission, China [H201626]
- Youth Scientific Research Fund of Nantong health and Family Planning Commission, Jiangsu, China [WQ2016072]
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MicroRNAs (miRNAs) have a great effect on regulating tumor cell migration, invasion, proliferation and prognosis. However, the mechanism of miR-1236-3p on regulating carcinogenesis is still unknown. In this study, the expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue. In lung adenocarcinoma A549 cell line, miR-1236-3p decreased ability of cell invasion and migration, furthermore, we show that KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8. Additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes. Overexpression of KLF8 can promote EMT -related genes at protein level. In conclusion, our results support the fact that miR-1236-3p acts as a tumor inhibitor in lung adenocarcinoma by suppressing the activity of KLF8, and it may play a critical role in the diagnosis and treatment of lung cancer. (C) 2017 Published by Elsevier Inc.
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