Journal
ANALYTICAL CHEMISTRY
Volume 89, Issue 20, Pages 11053-11060Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b03064
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Funding
- NASA Planetary Sciences Division, Science Mission Directorate [NNX16AJ25G]
- Society for Analytical Chemists of Pittsburgh
- NASA [NNX16AJ25G, 902572] Funding Source: Federal RePORTER
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Methods of performing precursor ion scans as well as neutral loss scans in a single linear quadrupole ion trap have recently been described. In this paper we report methodology for performing permutations of MS/MS scan modes, that is, ordered combinations of precursor, product, and neutral loss scans following a single ion injection event. Only particular permutations are allowed; the sequences demonstrated here are (1) multiple precursor ion scans, (2) precursor ion scans followed by a single neutral loss scan, (3) precursor ion scans followed by product ion scans, and (4) segmented neutral loss scans. (5) The common product ion scan can be performed earlier in these sequences, under certain conditions. Simultaneous scans can also be performed. These include multiple precursor ion scans, precursor ion scans with an accompanying neutral loss scan, and multiple neutral loss scans. We argue that the flew capability to perform complex simultaneous and sequential MSn operations on single ion populations represents a significant step in increasing the selectivity of mass spectrometry.
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