Journal
ANALYTICA CHIMICA ACTA
Volume 990, Issue -, Pages 54-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2017.08.014
Keywords
Vibrational optical activity; Vibrational Circular Dichroism; Supramolecular chirality; Absolute configuration; Amyloid fibrils; Protein aggregation
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Funding
- NIGMS NIH HHS [R35 GM142869] Funding Source: Medline
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Vibrational Circular Dichroism (VCD) is a unique and relatively new spectroscopic technique that is capable of determining an absolute configuration of chiral molecules. VCD can be also used to determine structure of large macromolecules. This review highlights the most recent advances of VCD in bio-analytical chemistry. It shows that VCD is capable of unraveling supramolecular organization of peptides, proteins, saccharides, glycerophospholipids, polypeptide microcrystals, as well as amyloid fibrils and DNA. This review also demonstrates how VCD can be utilized to explore molecule-molecule interactions that determine mechanisms of chiral separations in chromatography. It aims to attract attention of scientists from all different research areas demonstrating the strength and capability of this very powerful spectroscopic technique. (c). 2017 Elsevier B.V. All rights reserved.
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