Journal
NPJ REGENERATIVE MEDICINE
Volume 2, Issue -, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41536-017-0031-2
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Funding
- Research Project for Practical Applications of Regenerative Medicine from Japan Agency for Medical Research and Development (AMED)
- Creation of innovation centers for advanced interdisciplinary research areas ProgramYYY
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Air leaks (ALs) are observed after pulmonary resections, and without proper treatment, can produce severe complications. AL prevention is a critical objective for managing patients after pulmonary resection. This study applied autologous dermal fibroblast sheets (DFS) to close ALs. For sealing ALs in a 44-year-old male human patient with multiple bullae, a 5 x 15-mm section of skin was surgically excised. From this skin specimen, primary dermal fibroblasts were isolated and cultured for 4 weeks to produce DFSs that were harvested after a 10-day culture. ALs were completely sealed using surgical placement of these autologous DFSs. DFS were found to be a durable long-term AL sealant, exhibiting requisite flexibility, elasticity, durability, biocompatibility, and usability, resulting reliable AL closure. DFS should prove to be an extremely useful tissue-engineered pleura substitute.
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