Journal
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 12, Issue 10, Pages 1671-1679Publisher
AMER SOC NEPHROLOGY
DOI: 10.2215/CJN.01830217
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Funding
- Canadian Institutes of Health Research (CIHR)
- National Sciences and Engineering Research Council of Canada
- Physicians' Services Incorporated Foundation
- Astellas Pharma Canada [SG-185]
- St. Michael's Hospital Foundation
- Kidney Research Scientist Core Education and National Training Program New Investigator
- Canadian Diabetes Association Clinician Scientist salary support award
- CIHR New Investigator Award
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Background and objectives Fibrosis is a major cause of kidney allograft injury. Currently, the only means of assessing allograft fibrosis is by biopsy, an invasive procedure that samples <1% of the kidney. We examined whether magnetic resonance elastography, an imaging-based measure of organ stiffness, could noninvasively estimate allograft fibrosis and predict progression of allograft dysfunction. Design, setting, participants, & measurements Kidney allograft recipients >1 year post-transplant undergoing an allograft biopsy first underwent free-breathing, flow-compensated magnetic resonance elastography on a 3.0-T magnetic resonance imaging scanner. Each patient had serial eGFR measurements after the elastography scan for a follow-up period of up to 1 year. The mean stiffness value of the kidney allograft was compared with both the histopathologic Banff fibrosis score and the rate of eGFR change during the follow-up period. Results Sixteen patients who underwent magnetic resonance elastography and biopsy were studied (mean age: 54 9 years old). Whole-kidney mean stiffness ranged between 3.5 and 7.3 kPa. Whole-kidney stiffness correlated with biopsy-derived Banff fibrosis score (Spearman rho =0.67; P<0.01). Stiffness was heterogeneously distributed within each kidney, providing a possible explanation for the lack of a stronger stiffness-fibrosis correlation. We also found negative correlations between whole-kidney stiffness and both baseline eGFR (Spearman rho = -0.65; P<0.01) and eGFR change over time (Spearman rho = -0.70; P<0.01). Irrespective of the baseline eGFR, increased kidney stiffness was associated with a greater eGFR decline (regression r(2)=0.48; P=0.03). Conclusions Given the limitations of allograft biopsy, our pilot study suggests the potential for magnetic resonance elastography as a novel noninvasive measure of whole-allograft fibrosis burden that may predict future changes in kidney function. Future studies exploring the utility and accuracy of magnetic resonance elastography are needed.
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