Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 74, Issue 24, Pages 4455-4469Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2584-z
Keywords
Molecular imaging; Stem cell engraftment; Stem cell tracking; Cell imaging modalities
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Funding
- NIH/NCI Cancer Center Support [P30 CA008748]
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Cell fate is a concept used to describe the differentiation and development of a cell in its organismal context over time. It is important in the field of regenerative medicine, where stem cell therapy holds much promise but is limited by our ability to assess its efficacy, which is mainly due to the inability to monitor what happens to the cells upon engraftment to the damaged tissue. Currently, several imaging modalities can be used to track cells in the clinical setting; however, they do not satisfy many of the criteria necessary to accurately assess several aspects of cell fate. In recent years, reporter genes have become a popular option for tracking transplanted cells, via various imaging modalities in small mammalian animal models. This review article examines the reporter gene strategies used in imaging modalities such as MRI, SPECT/PET, Optoacoustic and Bioluminescence Imaging. Strengths and limitations of the use of reporter genes in each modality are discussed.
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