4.7 Article

Visible-light-mediated oxidative demethylation of N6-methyl adenines

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 77, Pages 10734-10737

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc05544g

Keywords

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Funding

  1. National Natural Science Foundation of China [21778057, 21502201, 21372224, 21420102003, 21232008]
  2. National Key R&D Program of China [2017YFA0208100, 2016YFA0602900]
  3. Beijing Natural Science Foundation [2162049]
  4. Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
  5. Shandong Province Independent Innovation and Achievements Transformation Special Fund [2014XGC06001]
  6. Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province [2016kf08]
  7. Chinese Academy of Sciences

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We report a simple protocol that affords oxidative demethylation of N-6-methyl groups in N-6-methyl adenines (m(6)A). The biologically compatible photocatalyst riboflavin prompts a highly selective C-H abstraction from N-6-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m(6)A and related N-methyl adenine analogues.

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