Journal
CHEMICAL RECORD
Volume 17, Issue 10, Pages 939-955Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201600141
Keywords
Diazo compounds; 1,3-Dipolar cycloaddition; Pyrazole; Withasomnine; Bestmann-Ohira reagent
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Funding
- DAE/BRNS, India
- SERB, DST, India
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1,3-Dipolar cycloaddition of diazo compounds with olefinic substrates is a promising atom-economic strategy for the construction of functionalized pyrazoles. Over the last few years, our group has been engaged in the synthesis of phosphonyl/sulfonylpyrazoles and pyrazole esters by employing Bestmann-Ohira Reagent (BOR) and its sulfur and ester analogs as 1,3-dipole precursors with various dipolarophiles. This account describes the novel synthetic methods developed in our laboratory, in the perspective of closely related work by others, for the synthesis of phosphonyl/sulfonylpyrazoles, pyrazole esters and the total synthesis of Withasomnine, a natural product, by using 1,3-dipolar cycloaddition as the key step.
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