Journal
ANAEROBE
Volume 47, Issue -, Pages 165-172Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2017.05.016
Keywords
Antimicrobial peptides; Streptococcus mutans; Dental caries; Biofilm; Oral bacteria
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Funding
- National Natural Science Foundation of China [21372026, 21402006, 21672019]
- Fundamental Research Funds for the Central Universities [20130801, XK1701, PYBZ1711]
- Peking University School of Stomatology [PKUSS20130210]
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Dental caries, a highly prevalent oral disease, is primarily caused by pathogenic bacteria infection, and most of them are anaerobic. Herein, we investigated the activity of a designed antimicrobial peptide ZXR-2, and found it showed broad-spectrum activity against a variety of Gram-positive and Gram-negative oral bacteria, particularly the caries-related taxa Streptococcus mutans. Time-course killing assays indicated that ZXR-2 killed most bacterial cells within 5 min at 4 x MIC. The mechanism of ZXR-2 involved disruption of cell membranes, as observed by scanning electron microscopy. Moreover, ZXR-2 inhibited the formation of S. mutans biofilm, but showed limited hemolytic effect. Based on its potent antimicrobial activity, rapid killing, and inhibition of S. mutans biofilm formation, ZXR-2 represents a potential therapeutic for the prevention and treatment of dental caries. (C) 2017 Elsevier Ltd. All rights reserved.
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