Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 211, Issue 4, Pages 223-+Publisher
ROYAL COLL PSYCHIATRISTS
DOI: 10.1192/bjp.bp.116.195651
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Funding
- Baily Thomas Charitable Trust [2315/1]
- Waterloo Foundation [WF918-1234]
- National Institute for Mental Health [5U01MH101724]
- Medical Research Council studentship [S.J.R.A.C. 1499282]
- Wellcome Trust [110222/7/15,2, 505714, 503141]
- medical Research Council [G0801418]
- Medical Research Council Programme [G0800509]
- Wellcome Trust ISSF
- Medical Research Council [G0801418, MR/L010305/1] Funding Source: researchfish
- MRC [G0801418, MR/N022572/1] Funding Source: UKRI
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Background 22q11.2 deletion syndrome (22q11.2DS) is associated with a high risk of childhood as well as adult psychiatric disorders, in particular schizophrenia. Childhood cognitive deterioration in 22q11.2DS has previously been reported, but only in studies lacking a control sample. Aims To compare cognitive trajectories in children with 22q11.2DS and unaffected control siblings. Method A longitudinal study of neurocognitive functioning (IQ, executive function, processing speed and attention) was conducted in children with 22q11.2DS (n =7 5, mean age time 1 (T-1) 9.9, time 2 (T-2) 12.5) and control siblings (n=33, mean age T-1 10.6, T-2 13.4). Results Children with 22q11.2DS exhibited deficits in all cognitive domains. However, mean scores did not indicate deterioration. When individual trajectories were examined, some participants showed significant decline over time, but the prevalence was similar for 22q11.2DS and control siblings. Findings are more likely to reflect normal developmental fluctuation than a 22q11.2DS-specific abnormality. Conclusions Childhood cognitive deterioration is not associated with 22q11.2DS. Contrary to previous suggestions, we believe it is premature to recommend repeated monitoring of cognitive function for identifying individual children with 22q11.2DS at high risk of developing schizophrenia.
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