Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 46, Issue -, Pages 44-49Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2017.06.008
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- National Institutes of Health, Institute of General Medical Sciences [P01 GM75334]
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Cell fate decisions are closely linked to changes in metabolic activity. Over recent years this connection has been implicated in mechanisms underpinning embryonic development, reprogramming and disease pathogenesis. In addition to being important for supporting the energy demands of different cell types, metabolic switching from aerobic glycolysis to oxidative phosphorylation plays a critical role in controlling biosynthetic processes, intracellular redox state, epigenetic status and reactive oxygen species levels. These processes extend beyond ATP synthesis by impacting cell proliferation, differentiation, enzymatic activity, ageing and genomic integrity. This review will focus on how metabolic switching impacts decisions made by multipotent cells and discusses mechanisms by which this occurs.
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