Journal
VACCINE
Volume 35, Issue 36, Pages 4796-4800Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.07.003
Keywords
Influenza vaccine; Effectiveness; Test-negative design; Control selection; Rapid diagnostic testing; Selection bias
Categories
Funding
- Health and Labour Science Research Grants from the Ministry of Health, Labour and Welfare of Japan
Ask authors/readers for more resources
Based on the unique characteristics of influenza, the concept of monitoring influenza vaccine effectiveness (VE) across the seasons using the same observational study design has been developed. In recent years, there has been a growing number of influenza VE reports using the test-negative design, which can minimize both misclassification of diseases and confounding by health care-seeking behavior. Although the test-negative designs offer considerable advantages, there are some concerns that widespread use of the test-negative design without knowledge of the basic principles of epidemiology could produce invalid findings. In this article, we briefly review the basic concepts of the test-negative design with respect to classic study design such as cohort studies or case-control studies. We also mention selection bias, which may be of concern in some countries where rapid diagnostic testing is frequently used in routine clinical practices, as in Japan. (C) 2017 The Authors. Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available