4.5 Article

Influenza epidemiology and immunization during pregnancy: Final report of a World Health Organization working group

Journal

VACCINE
Volume 35, Issue 43, Pages 5738-5750

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.08.037

Keywords

Influenza; Immunization; Pregnancy; Infants

Funding

  1. Centers for Disease Control and Prevention (CDC) [U50 CK000431]

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From 2014 to 2017, the World Health Organization convened a working group to evaluate influenza disease burden and vaccine efficacy to inform estimates of maternal influenza immunization program impact. The group evaluated existing systematic reviews and relevant primary studies, and conducted four new systematic reviews. There was strong evidence that maternal influenza immunization prevented influenza illness in pregnant women and their infants, although data on severe illness prevention were lacking. The limited number of studies reporting influenza incidence in pregnant women and infants under six months had highly variable estimates and underrepresented low- and middle-income countries. The evidence that maternal influenza immunization reduces the risk of adverse birth outcomes was conflicting, and many observational studies were subject to substantial bias. The lack of scientific clarity regarding disease burden or magnitude of vaccine efficacy against severe illness poses challenges for robust estimation of the potential impact of maternal influenza immunization programs. (C) 2017 The Authors. Published by Elsevier Ltd.

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