Journal
VACCINE
Volume 37, Issue 33, Pages 4710-4714Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.12.028
Keywords
Rabies; Blood-brain barrier; Mannitol; Therapy
Categories
Funding
- European FP7 Collaborative Project on Neglected Infectious Diseases in Central and Eastern Europe [602825]
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Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice. (C) 2017 Elsevier Ltd. All rights reserved.
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