Journal
VACCINE
Volume 35, Issue 18, Pages 2303-2307Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.03.026
Keywords
Foot-and-mouth disease; Vaccine matching
Categories
Funding
- FONCyT [PID 2012-0017]
- National Research Council (CONICET), Argentina
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Identifying vaccine strains to control outbreaks of foot-and-mouth disease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain with representative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species acceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination. (C) 2017 Elsevier Ltd. All rights reserved.
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