Journal
VACCINE
Volume 35, Issue 12, Pages 1586-1589Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.02.012
Keywords
MERS-CoV; Nanoparticle vaccine; Mouse model; Coronavirus
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Funding
- Novavax Inc.
- NIH [R01 AI095569]
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The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies in vivo, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection in vivo. (C) 2017 Elsevier Ltd. All rights reserved.
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