Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 158, Issue -, Pages 249-256Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.06.040
Keywords
Water-soluble amphiphilic polymer; MPC polymer; Polymer aggregate; Polymeric micelle; Solubilization; Paclitaxel
Funding
- Ministry of Education, Culture, Sports, Science and Technology of japan [2306]
- Japan Society for the Promotion of Science (JSPS) [17H02097]
- Grants-in-Aid for Scientific Research [17H02097] Funding Source: KAKEN
Ask authors/readers for more resources
To achieve stable and effective solubilization of poorly water-soluble bioactive compounds, water-soluble and amphiphilic polymers composed of hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) units and hydrophobic n-butyl methacrylate (BMA) units were prepared. MPC polymers having different molecular architectures, such as random-type monomer unit sequences and block-type sequences, formed polymer aggregates when they were dissolved in aqueous media. The structure of the random type polymer aggregate was loose and flexible. On the other hand, the block-type polymer formed polymeric micelles, which were composed of very stable hydrophobic poly(BMA) cores and hydrophilic poly(MPC) shells. The solubilization of a poorly water-soluble bioactive compound, paclitaxel (PTX), in the polymer aggregates was observed, however, solubilizing efficiency and stability were strongly depended on the polymer architecture; in other words, PTX stayed in the poly(BMA) core of the polymer micelle formed by the block-type polymer even when plasma protein was present in the aqueous medium. On the other hand, when the random-type polymer was used, PTX was transferred from the polymer aggregate to the protein. We conclude that water-soluble and amphiphilic MPC polymers are good candidates as solubilizers for poorly water-soluble bioactive compounds. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available