Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 77, Issue -, Pages 150-156Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2017.08.001
Keywords
MicroRNA; Hematopoiesis; Gene expression control; Immune regulation; Cytokine signaling
Categories
Funding
- Alzheimer's Association [AARF-16-443153]
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Majority of microRNAs are evolutionarily conserved in vertebrates. This is suggestive of their similar roles in regulation of gene networks. In addition to their conserved mature sequences and regulatory roles, a few microRNAs show very cell or tissue specific expression. These microRNAs are highly enriched in some cell types or organs. One such microRNA is microRNA-142 (miR-142). The classical stem-loop structure of miR142 encodes for two species of mature microRNAs; miR142-5p and miR142-3p. MiR142 is abundant in cells of hematopoietic origin, and therefore, aptly plays a role in lineage differentiation of hematopoietic cells. Interestingly, over the years, miR-142 has gained considerable attention for its quintessential role in regulating immune response. This mini-review discusses the important functional roles of miR-142 in inflammatory and immune response in different physiological and disease setting. (C) 2017 Elsevier Ltd. All rights reserved.
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