Journal
UROLOGIC CLINICS OF NORTH AMERICA
Volume 44, Issue 2, Pages 147-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ucl.2016.12.001
Keywords
Kidney cancer; Epidemiology; Incidence; Mortality; Treatment disconnect
Categories
Funding
- National Institutes of Health Institutional KL2 award [KL2TR000146-08]
- GEMSSTAR award [R03AG048091]
- Jahnigen Career Development Award
- Tippins Foundation Scholar Award
- Department of Defense Physician Research Training Award [W81XWH-14-1-0287]
- National Comprehensive Cancer Network Young Investigator Award
- Alfred A. Taubman Institute
- Myriad Genetics
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The incidence of kidney cancer has steadily increased over recent decades, with most new cases now found when lesions are asymptomatic and small. This downward stage migration relates to the increasing use of abdominal imaging. Three public health epidemics-smoking, hypertension, and obesity also play roles in the increase. Treatment mirrors the rise in incidence, with increasing interest in nephron-sparing therapies. Despite earlier detection and increasing treatment, the mortality rate has not decreased. This treatment disconnect phenomenon highlights the need to decrease unnecessary treatment of indolent tumors and address modifiable risk factors to reduce incidence and mortality.
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