Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 44, Issue 5, Pages 277-289Publisher
SPRINGER
DOI: 10.1007/s00249-015-1025-x
Keywords
Electroporation modeling; Drug and gene electrotransfer; Electrotransfer mechanisms; Electrochemotherapy
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Funding
- Research Council of Lithuania [TAP03/2011, MIP-034/2013]
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A short review of biophysical mechanisms for electrotransfer of biaoctive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.
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