Journal
GENETICS
Volume 207, Issue 2, Pages 413-446Publisher
OXFORD UNIV PRESS INC
DOI: 10.1534/genetics.117.300106
Keywords
Caenorhabditis elegans; ascarosides; glucose; fatty acids; phospholipids; sphingolipids; triacylglycerols; cholesterol; maradolipids; WormBook
Categories
Funding
- National Institutes of Health
- Swiss National Science Foundation
- European Union Horizon program
Ask authors/readers for more resources
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior. In this review, we outline lipid and carbohydrate structures as well as biosynthesis and breakdown pathways that have been characterized in C. elegans. We bring attention to functional studies using mutant strains that reveal physiological roles for specific lipids and carbohydrates during development, aging, and adaptation to changing environmental conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available