Journal
BRITISH JOURNAL OF CANCER
Volume 117, Issue 11, Pages 1644-1655Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2017.336
Keywords
non-small cell lung cancer; IL-10; IL-10R; PD1; PDL1
Categories
Funding
- IZKF in Erlangen [A59]
- Molecular Pneumology department, Thoracic Surgery and Institute of Pathology in Erlangen
- [SFB-643]
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Background: Lung cancer is the most life-threatening cancer type worldwide. Treatment options include surgery, radio- and chemotherapy, as well as the use of immunomodulatory antibodies. Interleukin (IL)-10 is an immunosuppressive cytokine involved in tumour immune escape. Methods: Immunohistochemistry (IHC) on human lung surgery tissue as well as human tumour cell line cultures, FACS analysis, real-time PCR and experimental lung cancer. Results: Here we discovered a positive correlation between IL-10 and IL-10 receptor (IL-10R) expression in the lung with tumour diameter in patients with lung cancer (non-small cell lung cancer), the most life-threatening cancer type worldwide. IL-10 and IL-10R were found induced in cells surrounding the lung tumour cells, and IL-10R was mainly expressed on the surface of Foxp-3(+) T-regulatory lymphocytes infiltrating the tumour of these patients where its expression inversely correlated with programmed cell death 1. These findings were confirmed in translational studies. In a human lung adenocarcinoma cell line, IL-10R was found induced under metabolic restrictions present during tumour growth, whereby IL-10 inhibited PDL1 and tumour cell apoptosis. Conclusions: These new findings suggest that IL-10 counteracts IFN-gamma effects on PD1/PDL1 pathway, resulting in possible resistance of the tumour to anti-PD1/PDL1 immunotherapy.
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